LIVE · 497 PROCEDURES · 115 CLINICS
✦ PROTOCOL · NO 09

Diabetes,
two ways.

An A1c that crept past 5.7. Morning numbers that won’t come down. A family history you can feel coming, or a diagnosis already in the chart. On the left, the standard-of-care workup: diagnosis, metformin, GLP-1s, monitoring. On the right, the metabolic and lifestyle protocol aimed at remission — alongside the meds, not instead.

A1c lab report + finger-prick testGLP-1 weekly injector penContinuous glucose monitor on forearmSlit-lamp dilated retinal exam
1 IN 3 · US ADULTS PREDIABETIC
2 TRACKS · 10 STEPS
UPDATED MAY 2026
TRACK · A · conventional

Conventional medicine

Type 2 diabetes is diagnosed, staged, and treated against A1c targets. Standard-of-care meds (metformin, GLP-1s, SGLT2s, insulin) have strong outcome data for heart, kidney, and eye complications.

TRACK · B · metabolic

Metabolic / lifestyle

Type 2 diabetes is largely a disease of insulin resistance, body composition, and food environment. The lifestyle track aims at remission or major dose-reduction — alongside meds, not instead of them, and never without a clinician on board.

Week 0
Diagnosis + baseline labs

Confirm with two of: fasting glucose ≥126, A1c ≥6.5, or OGTT ≥200. Baseline CMP, lipids, urine albumin, foot exam, dilated eye referral. Stage as prediabetes / T2DM.

$80–$220 PCP · $39–$95 tele · Family MD · internist
Day 0
KEEP YOUR TEAM

Never stop insulin, sulfonylureas, or SGLT2s without supervision — hypoglycemia and DKA risk. Tell your prescriber you’re changing diet so doses get adjusted. This page is for adjunct lifestyle work, not replacement of care.

$80–$520 visit · PCP / endo · non-negotiable
Week 1–4
First-line therapy

Metformin titrated to 1,000–2,000 mg / day. Add GLP-1 (semaglutide, tirzepatide) for A1c >8 or BMI ≥27. SGLT2 if CKD or CVD. Statin per ASCVD score. ACE inhibitor if microalbuminuria.

$4–$40 / mo metformin · $25–$1,300 / mo GLP-1 · PCP · endocrinology
Week 1–4
Carb quality + protein floor

Cut liquid sugar and ultra-processed carbs first. Build meals around 30–40 g protein + non-starchy vegetables + healthy fat. Many do well with <100 g carb / day; some go lower-carb / ketogenic under supervision.

$110–$220 RD visit · Registered dietitian · Dr. Jason Fung · Dr. Mark Hyman
Month 1–3
CGM + glucose monitoring

Continuous glucose monitor (Dexcom, Libre) for 2–4 weeks, then ongoing for insulin users. Otherwise fingerstick fasting + post-meal. Targets: fasting 80–130, 2-hr postprandial <180.

$80–$340 / mo CGM · $10–$40 / mo strips · PCP · pharmacy
Week 2–8
Walk after meals + Zone-2

10–20 min walk after each main meal (the highest-leverage glucose intervention there is). 3 × 30–45 min Zone-2 cardio / wk. Build to 7–10k steps daily.

$0–$120 / mo gym · Self · Dr. Peter Attia
Month 3–12
Intensify + complication screen

A1c every 3 mo. Stack therapy if >7%: add basal insulin, switch / add GLP-1. Annual: dilated eye exam, foot exam, urine albumin, lipids. Cardiology if ASCVD.

$220–$520 endo visit · $140–$320 retinal screen · Endocrinology · ophthalmology · podiatry
Week 4–16
Strength + body composition

2–3 × wk full-body strength training. Muscle is the largest glucose sink in the body. Aim for 5–10% bodyweight loss if BMI ≥27 — the single strongest predictor of remission.

$60–$140 / session trainer · Trainer or self · Dr. Gabrielle Lyon
Year 1+
Long-term management

A1c · 2–4 × yr. Annual complication screen. Vaccines (flu, pneumococcal, RSV, shingles, hepatitis B). Mental-health check — diabetes-related distress is common and undertreated.

$180–$420 / visit · PCP · multidisciplinary team
Ongoing
Sleep + stress + measurement

Sleep 7–9 hr — short sleep alone raises insulin resistance ~25%. Stress / cortisol management. Use CGM data to see your personal trigger foods. Re-check A1c every 3 mo.

$80–$340 / mo CGM · Self · CGM · therapist if needed
✦ THE METABOLIC SOURCES

Who built
track B.

All four sources are MDs or DOs. Track B is the lifestyle scaffolding to run alongside your prescribing clinician — dose adjustments stay with them.

Dr. Jason Fung
780K FOLLOWERS
Dr. Jason Fung
drjasonfung

T2DM is a disease of hyperinsulinemia. Carb restriction + time-restricted eating drive remission, not just A1c.

YouTube · booksVIEW →
Dr. Peter Attia
1.6M FOLLOWERS
Dr. Peter Attia
PeterAttiaMD

Walk after meals + strength training are the highest-leverage non-pharma interventions for insulin sensitivity.

Podcast · booksVIEW →
Dr. Mark Hyman
3.4M FOLLOWERS
Dr. Mark Hyman
drmarkhyman

Ultra-processed food is the engine of the T2DM epidemic. Food quality first, macros second.

Podcast · booksVIEW →
Dr. Gabrielle Lyon
1.2M FOLLOWERS
Dr. Gabrielle Lyon
drgabriellelyon

Muscle is the organ of longevity. Protein floor + resistance training is non-negotiable for metabolic health.

Podcast · booksVIEW →
CONVENTIONAL MEDICINE · SOURCES
  • ADA Standards of Care 2026Guidelines
  • UKPDS / DCCT long-term follow-upRCT cohort
  • AACE Comprehensive AlgorithmSpecialty body
METABOLIC / LIFESTYLE · SOURCES
  • DiRECT trial · dietary remission of T2DMRCT
  • Virta Health · 5-yr remission cohortClinical cohort
  • Dr. Jason Fung · The Diabetes CodeNephrologist · author
  • Dr. Peter Attia · OutliveMD · author